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Cremophor EL

CAS No. 61791-12-6

Cremophor EL( —— )

Catalog No. M35117 CAS No. 61791-12-6

Cremophor EL is a nonionic surfactant. cremophor EL inhibits cellular metabolism and suppresses UGT1A1-mediated rhodopsin glucuronidation.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Cremophor EL
  • Note
    Research use only, not for human use.
  • Brief Description
    Cremophor EL is a nonionic surfactant. cremophor EL inhibits cellular metabolism and suppresses UGT1A1-mediated rhodopsin glucuronidation.
  • Description
    Cremophor EL, a polyoxyethylene castor oil derivative, is a nonionic surfactant. Cremophor EL is widely employed to improve dissolution and delivery of agents.
  • In Vitro
    Cremophor EL is a widely used excipient. In the first 10 h, Cremophor EL at 5 mg/mL increases the impedance, then decreases it, and after 20 h of treatment, epithelial cell death is detected. Cremophor EL decreases cell viability and increases cell toxicity more than RH40. Both epithelial viability and monolayer integrity are seriously impaired at 10 to 50 mg/mL concentrations of Cremophor EL at 24-h treatment. Cremophor EL also enhances cell detachment.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    UGT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    61791-12-6
  • Formula Weight
    172.01
  • Molecular Formula
    C4H7Cl2NO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?Ethanol : 50 mg/mL (Ultrasonic)H2O : 25 mg/mL (Ultrasonic)
  • SMILES
    ——
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kiss L, et al. Kinetic analysis of the toxicity of pharmaceutical excipients Cremophor EL and RH40 on endothelial and epithelial cells. J Pharm Sci. 2013 Apr;102(4):1173-81.?
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